Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression.

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Article

Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression.

Journal of lipid research - 1 May 1992

Hwa J J, Zollman S, Warden C H, Taylor B A, Edwards P A, Fogelman A M, Lusis A J

Abstract excerpt

Inbred strains of mice exhibit large genetic variations in hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity. A tissue-specific genetic variation between the strains BALB/c and C57BL/6, resulting in about 5-fold higher levels in hepatic reductase activity in strain C57BL/6, was examined in detail. The activity difference between these two strains could be explained entirely by differences...

Topics

Animals
Base Sequence
Cholesterol
Cholesterol, Dietary
Cholestyramine Resin
Circadian Rhythm
Dietary Fats
Female
Gene Expression Regulation, Enzymologic
Genetic Variation
Hydroxymethylglutaryl CoA Reductases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent

Lipids

Liver

Lovastatin

Mice

Mice, Inbred Strains

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 1352323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1352323-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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