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Article

Functional promoter polymorphisms govern differential expression of HMG-CoA reductase gene in mouse models of essential hypertension.

PloS one - 31 Jan 2011

Sonawane Parshuram J, Sahu Bhavani S, Sasi Binu K, Geedi Parimala, Lenka Govinda, Mahapatra Nitish R

Abstract excerpt

3-Hydroxy-3-methylglutaryl-coenzyme A [HMG-CoA] reductase gene (Hmgcr) is a susceptibility gene for essential hypertension. Sequencing of the Hmgcr locus in genetically hypertensive BPH (blood pressure high), genetically hypotensive BPL (blood pressure low) and genetically normotensive BPN (blood pressure normal) mice yielded a number of single nucleotide polymorphisms (SNPs). BPH/BPL/BPN Hmgcr...

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Identifiers

PMID: 21304971
DOI: 10.1371/journal.pone.0016661
PMCID: PMC3031630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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