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Article

Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2008

Burkhardt Ralph, Kenny Eimear E, Lowe Jennifer K, Birkeland Andrew, Josowitz Rebecca, Noel Martha, Salit Jacqueline, Maller Julian B, Pe'er Itsik, Daly Mark J, Altshuler David, Stoffel Markus, Friedman Jeffrey M, Breslow Jan L

Abstract excerpt

UNLABELLED: Background- Variation in LDL-cholesterol (LDL-C) among individuals is a complex genetic trait involving multiple genes and gene-environment interactions. METHODS AND RESULTS: In a genome-wide association study (GWAS) to identify genetic variants influencing LDL-C in an isolated population from Kosrae, we observed associations for SNPs in the gene encoding 3hydroxy-3-methylglutaryl (HMG)-coenzyme A...

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Identifiers

PMID: 18802019
DOI: 10.1161/ATVBAHA.108.172288
PMCID: PMC2764366

Genes

HMGCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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