HMGCR gene polymorphism is associated with stroke risk in the EPIC-Norfolk study.

doi:10.1097/HJR.0b013e328330be77

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

HMGCR gene polymorphism is associated with stroke risk in the EPIC-Norfolk study.

European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology - 1 Feb 2010

Freitas Renata N, Khaw Kay-Tee, Wu Kelvin, Bowman Richard, Jeffery Hannah, Luben Robert, Wareham Nick J, Rodwell Sheila

Abstract excerpt

BACKGROUND: Earlier, a G/T single nucleotide polymorphism (SNP) in the HMGCR gene was shown to significantly reduce the overall serum lipids response to pravastatin. This study aimed to investigate the relationship of the rs17238540 SNP with coronary heart disease, stroke and cardiovascular disease risk. DESIGN: Cross-sectional study from the European Prospective Investigation into Cancer and Nutrition-Norfolk...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Pressure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coronary Disease

Share to Cross-Sectional Studies

Share to England

Share to Hydroxymethylglutaryl CoA Reductases

Share to Hypertension

Share to Logistic Models

Share to Stroke

Source

Open in PubMed

Identifiers

PMID: 19923996
DOI: 10.1097/HJR.0b013e328330be77

Genes

HMGCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HMGCR gene polymorphism is associated with stroke risk in the EPIC-Norfolk study.PMID 19923996Read ↗

Genetics: HMGCR and PCSK9 variants and cardiovascular risk.Semantic proximity Read ↗

Association of HMGCR rs17671591 and rs3761740 with lipidemia and statin response in Uyghurs and Han Chinese.Semantic proximity Read ↗

The effects of age and gender on the relationship between HMGCR promoter-911 SNP (rs33761740) and serum lipids in patients with coronary heart disease.Semantic proximity Read ↗

HMGCR rs17671591 SNP Determines Lower Plasma LDL-C after Atorvastatin Therapy in Chilean Individuals.Semantic proximity Read ↗

High-Risk Polymorphisms Associated with the Molecular Function of Human HMGCR Gene Infer the Impedance of Cholesterol BiosynthesisSemantic proximity Read ↗

High-Risk Polymorphisms Associated with the Molecular Function of Human HMGCR Gene Infer the Inhibition of Cholesterol Biosynthesis.Semantic proximity Read ↗

Gene Polymorphisms Affect the Effectiveness of Atorvastatin in Treating Ischemic Stroke Patients.Semantic proximity Read ↗

HMGCR gene polymorphism is associated with residual cholesterol risk in premature triple-vessel disease patients treated with moderate-intensity statins.Semantic proximity Read ↗

Common sequence variants in pharmacodynamic and pharmacokinetic pathway-related genes conferring LDL cholesterol response to statins.Semantic proximity Read ↗

Mendelian Randomization Reveals the Role of HMGCR in Pulmonary Arterial Hypertension Treatment, Independent of LDL Cholesterol ConcentrationSemantic proximity Read ↗

A single nucleotide polymorphism in the 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene ( HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk) study.Semantic proximity Read ↗

Influence of 6 genetic variants on the efficacy of statins in patients with dyslipidemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.