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Article

Metabolic Syndrome Induces Over Expression of the Human AT1R: A Haplotype-Dependent Effect With Implications on Cardio-Renal Function.

American journal of hypertension - 10 Mar 2018

Jain Sudhir, Puri Nitin, Rana Anita, Sirianni Natalie, Mopidevi Brahmaraju, Kumar Ashok

Abstract excerpt

BACKGROUND: The transcriptional regulation of the human angiotensin receptor subtype 1 (AT1R) gene in pathophysiologies, like the metabolic syndrome, is poorly understood. The human AT1R gene has polymorphisms in its promoter that can be arranged in 2 haplotypes. Variants -810T, -713T, -214A, and -153A always occur together (Hap-I) and variants -810A, -713G, -214C, and -153G form Hap-II. We have hypothesized that...

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Identifiers

PMID: 29036458
DOI: 10.1093/ajh/hpx176
PMCID: PMC5861552

Genes

NOX1
SOD1
STAT3

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