Article

High-Risk Polymorphisms Associated with the Molecular Function of Human HMGCR Gene Infer the Impedance of Cholesterol Biosynthesis

2021-08-17

Abstract excerpt

<h4>Background: </h4> HMG-CoA reductase or HMGCR (3-Hydroxy-3-methylglutaryl-CoA reductase) is a rate-limiting enzyme involved in cholesterol biosynthesis. HMGCR plays an important role in the possible occurrence of hypercholesterolemia leading to atherosclerosis and coronary heart disease. This enzyme is a major target for cholesterol lowering drugs such as “statins” which blocks the synthesis of mevalonate, a pr...

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Literature Corpus work: fab62127-7899-59a1-bf41-5e474ec37443
DOI: 10.21203/rs.3.rs-753324/v1

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