The effects of age and gender on the relationship between HMGCR promoter-911 SNP (rs33761740) and serum lipids in patients with coronary heart disease.

doi:10.1016/j.gene.2013.07.056

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The effects of age and gender on the relationship between HMGCR promoter-911 SNP (rs33761740) and serum lipids in patients with coronary heart disease.

Gene - 10 Oct 2013

Akadam-Teker Basak, Kurnaz Ozlem, Coskunpinar Ender, Daglar-Aday Aynur, Kucukhuseyin Ozlem, Cakmak Huseyin Altug, Teker Erhan, Bugra Zehra, Ozturk Oguz, Yilmaz-Aydogan Hulya

Abstract excerpt

BACKGROUND: Hydroxymethylglutaryl-Coenzyme A Reductase (HMGCR) catalyzes the rate-limiting step of cholesterol biosynthesis. This enzyme is the target of the widely available cholesterol lowering statins. In this population-based case-control study, the frequencies of -911 C>A polymorphism (rs3761740) of the HMGCR gene in patients with coronary heart disease (CHD) and healthy subjects were investigated and the...

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PMID: 23933271
DOI: 10.1016/j.gene.2013.07.056

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HMGCR

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