Article

Sorcin stimulates Activation Transcription Factor 6α (ATF6) transcriptional activity

2020-04-24

Abstract excerpt

<h4>ABSTRACT</h4> Levels of the transcription factor ATF6α, a key mediator of the unfolded protein response, that provides cellular protection during the progression endoplasmic reticulum (ER) stress, are markedly reduced in the pancreatic islet of patients with type 2 diabetes and in rodent models of the disease, including ob/ob and high fat-fed mice. Sorcin (gene name SRI ) is a calcium (Ca 2+ ) binding prote...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e32ebdb6-6661-51a3-850d-2f75b6f389b1
DOI: 10.1101/2020.04.23.053322

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sorcin stimulates Activation Transcription Factor 6α (ATF6) transcriptional activityDOI 10.1101/2020.04.23.053322Read

Whole-body sorcin invalidation does not cause hypothalamic ER stress nor worsens obesity in C57BL/6 male mice fed a westernized dietSemantic proximity Read

Effects of whole-body sorcin knockout on body weight and hypothalamic ER-stress in C57BL/6 male mice fed a westernized dietSemantic proximity Read

Small molecule-mediated insulin hypersecretion induces transient unfolded protein response and loss of beta cell functionSemantic proximity Read

GATA factors promote ER integrity and β-cell survival and contribute to type 1 diabetes risk.Semantic proximity Read

Dynamic Ca2+-Dependent Transcription Links Metabolic Stress to Impaired β-Cell IdentitySemantic proximity Read

A PDX1-ATF transcriptional complex governs β cell survival during stressSemantic proximity Read

OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes.Semantic proximity Read

Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic β-cell survival.Semantic proximity Read

Target deconvolution of an insulin hypersecretion-inducer acting through VDAC1 with a distinct transcriptomic signature in beta-cellsSemantic proximity Read

Endoplasmic reticulum stress induces a novel Ca <sup>2+</sup> signalling system initiated by Ca <sup>2+</sup> microdomainsSemantic proximity Read

Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibitionSemantic proximity Read

Soluble SorCS1 binds the insulin receptor to enhance insulin sensitivitySemantic proximity Read