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Article

GATA factors promote ER integrity and β-cell survival and contribute to type 1 diabetes risk.

Molecular endocrinology (Baltimore, Md.) - 1 Jan 2014

Sartori Daniel J, Wilbur Christopher J, Long Simon Y, Rankin Matthew M, Li Changhong, Bradfield Jonathan P, Hakonarson Hakon, Grant Struan F A, Pu William T, Kushner Jake A

Abstract excerpt

Pancreatic β-cell survival remains poorly understood despite decades of research. GATA transcription factors broadly regulate embryogenesis and influence survival of several cell types, but their role in adult β-cells remains undefined. To investigate the role of GATA factors in adult β-cells, we derived β-cell-inducible Gata4- and Gata6-knockout mice, along with whole-body inducible Gata4 knockouts. β-Cell Gata4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24284823
DOI: 10.1210/me.2013-1265
PMCID: PMC3874454

Genes

GATA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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