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Article

A PDX1-ATF transcriptional complex governs β cell survival during stress

1 Aug 2018

Abstract excerpt

OBJECTIVE: Loss of insulin secretion due to failure or death of the insulin secreting β cells is the central cause of diabetes. The cellular response to stress (endoplasmic reticulum (ER), oxidative, inflammatory) is essential to sustain normal β cell function and survival. Pancreatic and duodenal homeobox 1 (PDX1), Activating transcription factor 4 (ATF4), and Activating transcription factor 5 (ATF5) are...

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PMID: 30174228
DOI: 10.1016/j.molmet.2018.07.007

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