Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic β-cell survival.

The Journal of biological chemistry - 29 Jun 2018

Yuan Lin, Wang Huiyu, Liu Qi, Wang Zhe, Zhang Mingshu, Zhao Yan, Liang Kuo, Chen Liangyi, Xu Tao, Xu Pingyong

Abstract excerpt

Calcium homeostasis is essential for maintaining the viability and function of pancreatic β cells and plays a key role in preventing the development of diabetes. Decreased levels of ATPase sarcoplasmic/endoplasmic reticulum Ca2+-transporting 2 (ATP2a2), the main calcium pump in β cells, are often found in individuals with diabetes and in diabetic animal models. However, the regulators of ATP2a2 and the molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases
Share to Apoptosis Regulatory Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus

Share to Energy Metabolism

Share to Gene Knockout Techniques

Share to Homeostasis

Share to Insulin-Secreting Cells

Share to Sarcoplasmic Reticulum Calcium-Transporting ATPases

Source

Open in PubMed Open full text

Identifiers

PMID: 29769309
DOI: 10.1074/jbc.RA118.002399
PMCID: PMC6028951

Genes

CAMKK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic β-cell survival.PMID 29769309Read ↗

Polycystin-2 is cardioprotective against myocardial infarction by regulating the calcium-mediated ER stress responseSemantic proximity Read ↗

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein ResponseSemantic proximity Read ↗

Ca2+-Mediated Signaling Pathways: A Promising Target for the Successful Generation of Mature and Functional Stem Cell-Derived Pancreatic Beta Cells In VitroSemantic proximity Read ↗

Calcium-ATPases: Gene disorders and dysregulation in cancer.Semantic proximity Read ↗

Dynamic Ca2+-Dependent Transcription Links Metabolic Stress to Impaired β-Cell IdentitySemantic proximity Read ↗

A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis.Semantic proximity Read ↗

ATP6AP2 is robustly expressed in pancreatic β cells and neuroendocrine tumors, and plays a role in maintaining cellular viabilitySemantic proximity Read ↗

Activation of BK channels prevents diabetes-induced osteopenia by regulating mitochondrial Ca 2+ and SLC25A5/ANT2-PINK1-PRKN-mediated mitophagySemantic proximity Read ↗

A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes riskSemantic proximity Read ↗

Calcium signalling and ER stress in insulin resistance and atherosclerosisSemantic proximity Read ↗

The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse β cellsSemantic proximity Read ↗

Sorcin stimulates Activation Transcription Factor 6α (ATF6) transcriptional activitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.