Article

Endoplasmic reticulum stress induces a novel Ca <sup>2+</sup> signalling system initiated by Ca <sup>2+</sup> microdomains

2020-10-07

Abstract excerpt

The accumulation of unfolded proteins within the Endoplasmic Reticulum (ER) activates a signal transduction pathway termed the u nfolded p rotein response (UPR), which attempts to restore ER homeostasis. If homeostasis cannot be restored, UPR signalling ultimately induces apoptosis. Ca 2+ depletion in the ER is a potent inducer of ER stress. Despite the ubiquity of Ca 2+ as intracellular messenger, the precise...

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Literature Corpus work: 3a543672-441b-5a98-8689-51f26dfaf2a4
DOI: 10.1101/2020.10.07.328849

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