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Article

Dynamic Ca2+-Dependent Transcription Links Metabolic Stress to Impaired β-Cell Identity

17 Jun 2025

Abstract excerpt

By augmenting ATP-sensitive K+ channel–induced membrane depolarization, chronic metabolic stress in prediabetes may increase intracellular Ca2+ concentrations in pancreatic β-cells and cause a loss of cell identity and function. Here, we describe studies of the temporal transcriptomic dynamics induced by sulfonylurea-induced membrane depolarization. Gene expression in isolated islets is highly dynamic, with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40526459
DOI: 10.2337/db24-1141

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