Article

Small molecule-mediated insulin hypersecretion induces transient unfolded protein response and loss of beta cell function

2022-03-08

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic islet beta cells require a fine-tuned ER stress response for normal function; abnormal ER stress contributes to diabetes pathogenesis. Here, we identified a small molecule, SW016789, with time-dependent effects on beta cell ER stress and function. Acute treatment with SW016789 potentiated nutrient-induced calcium influx and insulin secretion, while chronic exposure to SW016789 transie...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9fd6b57-e757-5a6f-9554-ef9fdc65c197
DOI: 10.1101/2022.03.07.482881

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Small molecule-mediated insulin hypersecretion induces transient unfolded protein response and loss of beta cell functionDOI 10.1101/2022.03.07.482881Read

Target deconvolution of an insulin hypersecretion-inducer acting through VDAC1 with a distinct transcriptomic signature in beta-cellsSemantic proximity Read

Lipotoxicity Induces Beta Cell Small Extracellular Vesicle-mediated β-cell DysfunctionSemantic proximity Read

Dynamic Ca2+-Dependent Transcription Links Metabolic Stress to Impaired β-Cell IdentitySemantic proximity Read

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 DiabetesSemantic proximity Read

Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose DeprivationSemantic proximity Read

Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitusSemantic proximity Read

Recovery of human type 2 diabetes beta cell function associates with transcriptomic signatures that point to novel therapeutic targetsSemantic proximity Read

Metabolic features and regulation of the healing cycle—A new model for chronic disease pathogenesis and treatmentSemantic proximity Read

Sorcin stimulates Activation Transcription Factor 6α (ATF6) transcriptional activitySemantic proximity Read

Differential effects of voclosporin and tacrolimus on insulin secretion from human isletsSemantic proximity Read

A pipeline for natural small molecule inhibitors of endoplasmic reticulum stressSemantic proximity Read

Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetesSemantic proximity Read