Article

Target deconvolution of an insulin hypersecretion-inducer acting through VDAC1 with a distinct transcriptomic signature in beta-cells

2024-12-26

Abstract excerpt

<h4>ABSTRACT</h4> Obesity, insulin resistance, and a host of environmental and genetic factors can drive hyperglycemia, causing β-cells to compensate by increasing insulin production and secretion. In type 2 diabetes (T2D), β-cells under these conditions eventually fail. Rare β-cell diseases like congenital hyperinsulinism (HI) also cause inappropriate insulin secretion, and some HI patients develop diabetes. How...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5a2a8377-e2bf-5b36-b137-641859047ec0
DOI: 10.1101/2024.12.26.629558

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Target deconvolution of an insulin hypersecretion-inducer acting through VDAC1 with a distinct transcriptomic signature in beta-cellsDOI 10.1101/2024.12.26.629558Read

Small molecule-mediated insulin hypersecretion induces transient unfolded protein response and loss of beta cell functionSemantic proximity Read

Wolfram syndrome 2 gene (CISD2) deficiency disrupts Ca2+-mediated insulin secretion in β-cellsSemantic proximity Read

Lipotoxicity Induces Beta Cell Small Extracellular Vesicle-mediated β-cell DysfunctionSemantic proximity Read

Calcium-dependent transcriptional profiles of human pancreatic islet cells reveal functional diversity in islet subpopulationsSemantic proximity Read

Dynamic Ca2+-Dependent Transcription Links Metabolic Stress to Impaired β-Cell IdentitySemantic proximity Read

β-cell NCK1 is reduced in type 2 diabetes, leading to inefficient β-cell UPR and insulin secretion and revealing sex-specific adaptation during metabolic stressSemantic proximity Read

Large-Scale Functional Genomics Screen to Identify Modulators of Human β-Cell Insulin SecretionSemantic proximity Read

Characterization of the secretome, transcriptome and proteome of human β cell line EndoC-βH1Semantic proximity Read

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 DiabetesSemantic proximity Read

Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion.Semantic proximity Read

A reference map of the human proinsulin biosynthetic interaction networkSemantic proximity Read

Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitusSemantic proximity Read