Article

Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition

2021-02-17

Abstract excerpt

<h4>ABSTRACT</h4> The endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) helps decide β cell survival in diabetes. The alternative eukaryotic initiation factor 2A (EIF2A) has been proposed to mediate EIF2S1-independent translation during cellular stress and viral infection, but its role in β cells is unknown. EIF2A abundance is high in human and mouse islets relative to other tissues, and b...

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Literature Corpus work: ec47a516-526b-56c1-9751-249e04bac9e7
DOI: 10.1101/2021.02.17.431676

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