Article

Effects of whole-body sorcin knockout on body weight and hypothalamic ER-stress in C57BL/6 male mice fed a westernized diet

2022-10-14

Abstract excerpt

<title>Abstract</title> Background Soluble Resistance Related Calcium Binding Protein (sorcin) is a calcium (Ca2+) binding protein which has been shown to play a role in maintaining intracellular endoplasmic reticulum (ER) Ca2+ stores and lowering ER stress. Recently, our lab has demonstrated that sorcin expression was downregulated in the islets of Langerhans of mice fed a high-fat diet...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3dcfbd7c-f91f-5ddd-a881-21fb7e62c70c
DOI: 10.21203/rs.3.rs-2136059/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effects of whole-body sorcin knockout on body weight and hypothalamic ER-stress in C57BL/6 male mice fed a westernized dietDOI 10.21203/rs.3.rs-2136059/v1Read

Whole-body sorcin invalidation does not cause hypothalamic ER stress nor worsens obesity in C57BL/6 male mice fed a westernized dietSemantic proximity Read

Sorcin stimulates Activation Transcription Factor 6α (ATF6) transcriptional activitySemantic proximity Read

Sorting receptor SORCS2 facilitates a protective stress response in pancreatic isletsSemantic proximity Read

Soluble SorCS1 binds the insulin receptor to enhance insulin sensitivitySemantic proximity Read

SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells.Semantic proximity Read

Chop / Ddit3 depletion in β-cells alleviates ER stress and corrects hepatic steatosisSemantic proximity Read

Adipocyte-specific ablation of the Ca 2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissueSemantic proximity Read

Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice.Semantic proximity Read

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.Semantic proximity Read

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.Semantic proximity Read

A murine model of the human CREBRF R457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stressSemantic proximity Read