Article

Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset

2024-04-28

Abstract excerpt

Autoimmune destruction of pancreatic β cells results in type 1 diabetes (T1D), with pancreatic immune infiltrate representing a key feature in this process. Studies of human T1D immunobiology have predominantly focused on circulating immune cells in the blood, while mouse models suggest diabetogenic lymphocytes primarily reside in pancreas-draining lymph nodes (pLN). A comprehensive study of immune cells in human...

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Literature Corpus work: e32db07f-beda-51ed-a504-7c5c853e6266
DOI: 10.1101/2024.04.23.590798

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