Article

Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes

2025-05-24

Abstract excerpt

<h4>SUMMARY</h4> This study explores the inflammatory response observed in pancreata and pancreatic lymph node (pLN) samples obtained throughout the natural history of type 1 diabetes (T1D) including non-diabetic individuals and non-diabetic autoantibody positive individuals with high susceptibility using spatial transcriptomics (ST). Integration of ST with public single-cell RNA sequencing data enabled interroga...

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Literature Corpus work: 6b4c27a9-3ef3-528f-aafa-184a6a3c33fa
DOI: 10.1101/2025.05.19.654940

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