Article

Multiomics single-cell analysis of human pancreatic islets reveals novel cellular states in health and type 1 diabetes

2021-01-29

Abstract excerpt

Type 1 diabetes (T1D) is an autoimmune disease of only partially defined etiology in which immune cells destroy insulin-producing beta cells. Using single-cell transcriptomics and an advanced analytical strategy to assess pancreatic islets of T1D, autoantibody-positive, and non-diabetic organ donors, we identified both canonical cell types and rare insulin-expressing cells with a hybrid mixture of endocrine and ex...

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Literature Corpus work: dd8a28c8-ff48-5eed-b051-f79418b39c0b
DOI: 10.1101/2021.01.28.428598

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