Article

Aberrant TNF signaling in pancreatic lymph nodes of patients with Type 1 Diabetes

2024-06-03

Abstract excerpt

The therapeutic landscape for Type 1 Diabetes (T1D) is rapidly changing as ongoing clinical trials aim to delay beta-cell loss by inhibiting proinflammatory cytokines. However, the precise timing and cellular contexts of cytokine dysregulation remains unknown. We generated the largest existing measurement of gene expression and chromatin accessibility in ∼1 million immune cells from the pancreatic lymph nodes and...

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Literature Corpus work: 3c65a0af-02ae-57b1-93c4-974be6b4ee2c
DOI: 10.1101/2024.05.31.596885

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