Article
Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood.
Science advances - 13 Feb 2026
Rawat Puneet, Shapiro Melanie R, Peters Leeana D, Widrich Michael, Mayer-Blackwell Koshlan, Motwani Keshav, Pavlović Milena, Al Hajj Ghadi, Posgai Amanda L, Kanduri Chakravarthi, Isacchini Giulio, Chernigovskaya Maria, Scheffer Lonneke, Motwani Kartik, Balzano-Nogueira Leandro Octavio, Pettenger-Willey Camryn M, Valkiers Sebastiaan, Jacobsen Laura M, Haller Michael J, Schatz Desmond A, Wasserfall Clive H, Emerson Ryan O, Fiore-Gartland Andrew J, Atkinson Mark A, Klambauer Günter, Sandve Geir Kjetil, Greiff Victor, Brusko Todd M
Abstract excerpt
Type 1 diabetes (T1D) is a T cell-mediated disease with a strong immunogenetic human leukocyte antigen (HLA) dependence. HLA allelic influence on the T cell receptor (TCR) repertoire shapes thymic selection and controls activation of diabetogenic clones yet remains largely unresolved in T1D. We sequenced the circulating TCRβ chain repertoire from 2250 HLA-typed participants across three cross-sectional cohorts,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.