Article

Single-Cell Mapping Identifies CD14⁺ Macrophages as Central Orchestrators of CD8⁺ T Cell–Driven Immune Niches in clinical Type 1 diabetes

2026-08-12

Abstract excerpt

Type 1 diabetes (T1D) is an autoimmune disease characterized by CD8⁺ T cell-mediated destruction of pancreatic β cells; however, the cellular interactions that organize immune activation within human islets remain poorly understood. Here, we integrated thirteen CD45⁺ immune cell single-cell RNA sequencing datasets from human islets spanning non-diabetic donors, stage 3 T1D, and type 2 diabetes (T2D) to comprehensi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cfe69748-60a6-53c9-87e4-6ef68b367a47
DOI: 10.64898/2026.08.06.743319

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-Cell Mapping Identifies CD14⁺ Macrophages as Central Orchestrators of CD8⁺ T Cell–Driven Immune Niches in clinical Type 1 diabetesDOI 10.64898/2026.08.06.743319Read

Interactions between islet-resident macrophages and β cells in diabetesSemantic proximity Read

Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes.Semantic proximity Read

Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetesSemantic proximity Read

Dynamic remodeling of the pancreas immune landscape in obesitySemantic proximity Read

Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progressionSemantic proximity Read

Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onsetSemantic proximity Read

Systematic immune cell dysregulation and molecular subtypes revealed by single-cell RNA-seq of subjects with type 1 diabetesSemantic proximity Read

Single-cell sequencing unveils distinct immune microenvironment with CCR6-CCL20 crosstalk in human chronic pancreatitisSemantic proximity Read

Synthetic Immunological Niche Reveals Early Immune Dysregulation and Stratifies Therapeutic Response in Type 1 DiabetesSemantic proximity Read

Dynamic remodeling of the pancreas immune landscape in obesitySemantic proximity Read

Adipose tissue macrophage heterogeneity in the single-cell genomics eraSemantic proximity Read

Aberrant immune regulation and enrichment of stem-like CD8 <sup>+</sup> T cells in the pancreatic lymph node during type 1 diabetes developmentSemantic proximity Read