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Aberrant immune regulation and enrichment of stem-like CD8 <sup>+</sup> T cells in the pancreatic lymph node during type 1 diabetes development

2025-05-27

Abstract excerpt

<h4>Summary</h4> Effector CD8 + T cells are key cellular drivers of type 1 diabetes (T1D) pathogenesis, yet questions remain regarding the molecular defects leading to altered cytotoxicity, their signature in peripheral tissues, and their receptor specificity. Thus, we analyzed human pancreatic lymph nodes (pLN) using mass cytometry and single cell RNA sequencing (scRNAseq) with combined proteomic and T cell rec...

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Literature Corpus work
722acbaa-804e-5de1-aae4-64baf9f263c6
DOI
10.1101/2025.05.23.655848
Open publication

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