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Human immune phenotyping reveals accelerated aging in type 1 diabetes

27 Jul 2023

Abstract excerpt

The proportions and phenotypes of immune cell subsets in peripheral blood undergo continual and dramatic remodeling throughout the human life span, which complicates efforts to identify disease-associated immune signatures in type 1 diabetes (T1D). We conducted cross-sectional flow cytometric immune profiling on peripheral blood from 826 individuals (stage 3 T1D, their first-degree relatives, those with ≥2 islet...

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PMID: 37498686
DOI: 10.1172/jci.insight.170767

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