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Article

Type 1 Diabetes: A Guide to Autoimmune Mechanisms for Clinicians.

Diabetes, obesity & metabolism - 1 Aug 2025

Mauvais François-Xavier, van Endert Peter M

Abstract excerpt

Type 1 diabetes (T1D) results from the destruction of pancreatic beta cells by autoreactive T lymphocytes, leading to insulin deficiency and lifelong insulin dependence. It develops in genetically predisposed individuals, triggered by environmental or immunological factors. Although the exact causes of T1D remain unknown, the autoimmune pathogenesis of the disease is clearly indicated by the genetic risk...

Topics

Humans
Diabetes Mellitus, Type 1
Autoimmunity
Insulin-Secreting Cells
Autoantibodies
Genetic Predisposition to Disease
Islets of Langerhans

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40375390
DOI: 10.1111/dom.16460
PMCID: PMC12312826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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