Article

Recent advances in high-throughput approaches to dissect enhancer function

2017-06-19

Abstract excerpt

The regulation of gene transcription in higher eukaryotes is accomplished through the involvement of transcription start site (TSS)-proximal (promoters) and -distal (enhancers) regulatory elements. It is now well acknowledged that enhancer elements play an essential role during development and cell differentiation, while genetic alterations in these elements are a major cause of human disease. Many strategies have...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e32d3b66-8838-5a9b-bb89-3baf834efcfb
DOI: 10.12688/f1000research.11581.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Recent advances in high-throughput approaches to dissect enhancer functionDOI 10.12688/f1000research.11581.1Read

Enhancers: five essential questions.Semantic proximity Read

Transcriptional Enhancers: Bridging the Genome and Phenome.Semantic proximity Read

Enhancer biology and enhanceropathies.Semantic proximity Read

Functional anatomy of distant-acting mammalian enhancers.Semantic proximity Read

Comprehensive Evaluation of Diverse Massively Parallel Reporter Assays to Functionally Characterize Human Enhancers Genome-wideSemantic proximity Read

Functional dissection of the enhancer repertoire in human embryonic stem cellsSemantic proximity Read

Mammalian enhancers and GWASs act proximally and seldom skip active genesSemantic proximity Read

Exonic enhancers are a widespread class of dual-function regulatory elements.Semantic proximity Read

Massively Parallel Reporter Assays identify enhancer elements in Oesophageal AdenocarcinomaSemantic proximity Read

Exonic enhancers are a widespread class of dual-function regulatory elementsSemantic proximity Read

A genome-wide nucleosome-resolution map of promoter-centered interactions in human cells corroborates the enhancer-promoter looping modelSemantic proximity Read

From remote enhancers to gene regulation: charting the genome's regulatory landscapes.Semantic proximity Read