Article

Massively Parallel Reporter Assays identify enhancer elements in Oesophageal Adenocarcinoma

2024-06-11

Abstract excerpt

Cancer is a disease underpinned by aberrant gene expression. Enhancers are regulatory elements that play a major role in transcriptional control and changes in active enhancer function are likely critical in the pathogenesis of oesophageal adenocarcinoma (OAC). Here, we utilise STARR-seq to profile the genome-wide enhancer landscape in OAC and identify hundreds of high-confidence enhancer elements. These regions a...

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Literature Corpus work: 03be9a84-4990-56c5-9753-265eb0e33e50
DOI: 10.1101/2024.06.11.598412

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