Article

A genome-wide nucleosome-resolution map of promoter-centered interactions in human cells corroborates the enhancer-promoter looping model

2023-02-13

Abstract excerpt

The enhancer-promoter looping model, in which enhancers activate their target genes via physical contact, has long dominated the field of gene regulation. However, the ubiquity of this model has been questioned due to evidence of alternative mechanisms and the lack of its systematic validation, primarily owing to the absence of suitable experimental techniques. In this study, we present a new MNase-based proximity...

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Literature Corpus work: dfe46ffb-e3dc-5906-9767-655c388d307f
DOI: 10.1101/2023.02.12.528105

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