Functional anatomy of distant-acting mammalian enhancers.

doi:10.1098/rstb.2012.0359

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Article

Functional anatomy of distant-acting mammalian enhancers.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 1 Jan 2013

Dickel D E, Visel A, Pennacchio L A

Abstract excerpt

Transcriptional enhancers are a major class of functional element embedded in the vast non-coding portion of the human genome. Acting over large genomic distances, enhancers play critical roles in the tissue and cell type-specific regulation of genes, and there is mounting evidence that they contribute to the aetiology of many human diseases. Methods for genome-wide mapping of enhancer regions are now available,...

Topics

Alleles
Animals
Binding Sites
Enhancer Elements, Genetic
Extremities
Gene Expression Regulation, Developmental
Genetic Diseases, Inborn
Humans
Mammals
Mutation
Organ Specificity
Transcription Factors
Transcriptional Activation

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Identifiers

PMID: 23650633
DOI: 10.1098/rstb.2012.0359
PMCID: PMC3682724

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