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Article

Exonic enhancers are a widespread class of dual-function regulatory elements.

Nature communications - 2 Apr 2026

Mouren Jean-Christophe, Torres Magali, van Ouwerkerk Antoinette, Manosalva Iris, Gallardo Frederic, Spicuglia Salvatore, Ballester Benoit

Abstract excerpt

Exonic enhancers (EEs) occupy an under-appreciated niche in gene regulation. By integrating transcription factor binding, chromatin accessibility, and high-throughput enhancer-reporter assays, we demonstrate that many protein-coding exons possess enhancer activity across species. These candidate EEs (cEEs) exhibit characteristic epigenomic signatures, form long-range interactions with gene promoters, and can be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41927541
DOI: 10.1038/s41467-026-71220-6
PMCID: PMC13216554

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