Article
Enhancer biology and enhanceropathies.
Nature structural & molecular biology - 1 Mar 2014
Smith Edwin, Shilatifard Ali
Abstract excerpt
Enhancers are cis-regulatory elements that enable precise spatiotemporal patterns of gene expression during development and are notable for being able to function at large distances from their target genes. Such regulatory elements often bypass intervening genes and typically comprise binding sites for multiple transcription factors that can also be transcribed by RNA polymerase II (Pol II) to produce noncoding...
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