Article

Comprehensive Evaluation of Diverse Massively Parallel Reporter Assays to Functionally Characterize Human Enhancers Genome-wide

2025-03-27

Abstract excerpt

Massively parallel reporter assays (MPRAs) and self-transcribing active regulatory region sequencing (STARR-seq) have revolutionized enhancer characterization by enabling high-throughput functional assessment of regulatory sequences. Here, we systematically evaluated six MPRA and STARR-seq datasets generated in the human K562 cell line and found substantial inconsistencies in enhancer calls from different labs tha...

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Literature Corpus work: 2d7b9974-5d46-5491-9bc7-d3f4c637e2e3
DOI: 10.1101/2025.03.25.645321

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