Article

Exonic enhancers are a widespread class of dual-function regulatory elements

2025-04-01

Abstract excerpt

Exonic enhancers (EEs) occupy an under-appreciated niche in gene regulation. By integrating transcription factor binding, chromatin accessibility, and high-throughput enhancer-reporter assays, we demonstrate that many protein-coding exons possess enhancer activity across species. These EEs exhibit characteristic epigenomic signatures, form long-range interactions with gene promoters, and can be altered by both non...

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Literature Corpus work: 49c36deb-79ea-5714-812b-7bc44623f5fb
DOI: 10.1101/2025.03.27.645641

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