Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes.

Diabetes - 1 Jan 2008

Tritt Michael, Sgouroudis Evridiki, d'Hennezel Eva, Albanese Alexandre, Piccirillo Ciriaco A

Abstract excerpt

OBJECTIVE: In this study, we asked whether a possible quantitative or qualitative deficiency in naturally occurring Foxp3(+)CD4(+) regulatory T-cells (nT(reg)), which display potent inhibitory effects on T-cell functions in vitro and in vivo, may predispose to the development of type 1 diabetes. RESEARCH DESIGN AND METHODS: We assessed the frequency and function of Foxp3(+) nT(reg) cells in primary and secondary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adoptive Transfer
Share to Islets of Langerhans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ki-67 Antigen

Share to Lymphocyte Count

Share to Mice, Inbred NOD

Share to Pancreas

Share to T-Lymphocyte Subsets

Share to T-Lymphocytes, Regulatory

Source

Identifiers

PMID: 17928397
DOI: 10.2337/db06-1700

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes.PMID 17928397Read ↗

Selective ablation of thymic and peripheral Foxp3 <sup>+</sup> regulatory T cell developmentSemantic proximity Read ↗

Peripherally-induced regulatory T cells contribute to the control of autoimmune diabetesSemantic proximity Read ↗

Revisiting regulatory T cells in type 1 diabetesSemantic proximity Read ↗

Regulatory T cells in human autoimmune diseases.Semantic proximity Read ↗

Functional dynamics of Foxp3⁺ regulatory T cells in mice and humans.Semantic proximity Read ↗

Transient Depletion of Foxp3+ Regulatory T Cells Selectively Promotes Aggressive β Cell Autoimmunity in Genetically Susceptible DEREG Mice.Semantic proximity Read ↗

CD8+ Foxp3+ T cells share developmental and phenotypic features with classical CD4+ Foxp3+ regulatory T cells but lack potent suppressive activity.Semantic proximity Read ↗

Identification and characterization of T reg-like cells in zebrafish.Semantic proximity Read ↗

Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus.Semantic proximity Read ↗

Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice.Semantic proximity Read ↗

Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells.Semantic proximity Read ↗

Gata3 is detrimental to regulatory T cell function in autoimmune diabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.