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Article

Transient Depletion of Foxp3+ Regulatory T Cells Selectively Promotes Aggressive β Cell Autoimmunity in Genetically Susceptible DEREG Mice.

Frontiers in immunology - 1 Jan 2021

Watts Deepika, Janßen Marthe, Jaykar Mangesh, Palmucci Francesco, Weigelt Marc, Petzold Cathleen, Hommel Angela, Sparwasser Tim, Bonifacio Ezio, Kretschmer Karsten

Abstract excerpt

Type 1 diabetes (T1D) represents a hallmark of the fatal multiorgan autoimmune syndrome affecting humans with abrogated Foxp3+ regulatory T (Treg) cell function due to Foxp3 gene mutations, but whether the loss of Foxp3+ Treg cell activity is indeed sufficient to promote β cell autoimmunity requires further scrutiny. As opposed to human Treg cell deficiency, β cell autoimmunity has not been observed in...

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Identifiers

PMID: 34447385
DOI: 10.3389/fimmu.2021.720133
PMCID: PMC8382961

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