Article

Peripherally-induced regulatory T cells contribute to the control of autoimmune diabetes

2017-10-07

Abstract excerpt

Type 1 diabetes (T1D) results from the autoimmune destruction of pancreatic beta cells and is partly caused by deficiencies in the Foxp3 + regulatory T cell (Treg) compartment. Conversely, therapies that increase Treg function can prevent autoimmune diabetes in animal models. The majority of Tregs develop in the thymus (tTregs), but a proportion of Foxp3 + Tregs is generated in the periphery (pTregs) from Foxp3...

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Literature Corpus work: 7c778226-523b-5696-b0ce-9ad2987cf02e
DOI: 10.1101/199646

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