Article
Development and function of Foxp3(+) regulatory T cells.
Nephrology (Carlton, Vic.) - 1 Feb 2016
Wang Yuan Min, Ghali Joanna, Zhang Geoff Yu, Hu Min, Wang Ya, Sawyer Andrew, Zhou Jimmy Jianheng, Hapudeniya Dhanushka A, Wang Yiping, Cao Qi, Zheng Guoping, Harris David C, Alexander Stephen I
Abstract excerpt
Regulatory T cells (Tregs) have been recognized as having a major role in maintaining peripheral tolerance and preventing and limiting autoimmune and chronic inflammatory diseases. Tregs derive from the thymus and also develop peripherally. In this review, we discuss recent progress in our understanding of the basic mechanisms involved in Treg development and function in protecting against autoimmunity in the...
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