How defects in central tolerance impinge on a deficiency in regulatory T cells.

Abstract excerpt

Both central (thymic) and peripheral (nonthymic) mechanisms are important for the induction and maintenance of T cell tolerance. Mice with a defect in Foxp3, required for the generation and activity of CD4(+)CD25(+) regulatory T cells, exhibit massive lymphoproliferation and severe inflammatory infiltration of multiple organs, in particular the lungs, liver, and skin. We have explored how this phenotype is...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to AIRE Protein
• Share to Autoimmunity
• Share to Forkhead Transcription Factors