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Functional Dichotomy of Developmental Foxp3 <sup>+</sup> Treg Cell Subsets in the Visceral Adipose Tissue of Lean and Obese Mice

2025-03-14

Abstract excerpt

<h4>SUMMARY</h4> Chronic inflammation and loss of Foxp3 + regulatory T (Treg) cells in the visceral adipose tissue (VAT) are hallmarks of the pathogenesis of insulin resistance and obesity. This study explores the roles of VAT Treg cells from thymic (tTreg) and peripheral (pTreg) developmental origin, revealing their opposing roles in metabolic inflammation. Obesity destabilized VAT tTreg cells, causing them to...

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Identifiers and source

Literature Corpus work
2aadb303-0409-5b90-86fd-2a2892196a71
DOI
10.1101/2025.03.12.642664
Open publication

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