Polygenic risk for Alzheimer’s disease shapes microglial inflammatory and antigen-presentation programs in vivo

Abstract excerpt

<title>Abstract</title> <p>How polygenic risk translates into cellular dysfunction remains largely unknown in Alzheimer’s disease and related disorders. Here, we selected 31 donors broadly spanning the Caucasian-based polygenic risk distribution for AD and show that human polygenic architecture modulates microglial immune responses to amyloid pathology in vivo. We developed a “microglia village” model by xenotran...

Topics

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• Alzheimer Disease
• Brain
• Disease Models, Animal
• Genetic Predisposition to Disease
• Genetic Variation
• Genome-Wide Association Study
• Microglia
• Neuroinflammation and Neurodegeneration Mechanisms

Identifiers and source

Literature Corpus work

e24bc290-8b15-5cb9-9874-91a762617d3a

DOI

10.21203/rs.3.rs-7794221/v1