Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’s disease

Abstract excerpt

Microglia are now considered drivers of Alzheimer’s disease (AD) pathology. However, single-cell RNA-sequencing (scRNA-seq) of microglia in mice, a key preclinical model organsim, have shown mixed results regarding translatability to human studies. To address this, scRNA-seq of microglia from C57BL/6J (B6) and wild-derived strains WSB/EiJ, CAST/EiJ and PWK/PhJ carrying APP/PS1 was performed and demonstrated that...

Topics

Open a Topic to create a Post that cites this publication.

• Alzheimer Disease
• Disease Models, Animal
• Genetic Variation
• Genome-Wide Association Study
• Mice
• Microglia
• RNA-Seq
• Species Specificity

Identifiers and source

Literature Corpus work

9416eafa-0d96-5daf-b0ea-b553abffc98f

DOI

10.1101/2020.06.02.130237