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Article

Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer's disease.

Cell reports - 9 Feb 2021

Yang Hongtian Stanley, Onos Kristen D, Choi Kwangbom, Keezer Kelly J, Skelly Daniel A, Carter Gregory W, Howell Gareth R

Abstract excerpt

Genetic and genome-wide association studies suggest a central role for microglia in Alzheimer's disease (AD). However, single-cell RNA sequencing (scRNA-seq) of microglia in mice, a key preclinical model, has shown mixed results regarding translatability to human studies. To address this, scRNA-seq of microglia from C57BL/6J (B6) and wild-derived strains (WSB/EiJ, CAST/EiJ, and PWK/PhJ) with and without APP/PS1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33567283
DOI: 10.1016/j.celrep.2021.108739
PMCID: PMC7937391

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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