Article

PICALM regulates a human microglial antigen presentation program in Alzheimer’s disease

2026-06-09

Abstract excerpt

<title>Abstract</title> <p>Microglia surrounding amyloid plaques in Alzheimer’s disease (AD) strongly upregulate HLA class II genes, but whether this transcriptional state reflects antigen presentation, and how it relates to genetic risk, remains unclear. Here we identify a broad repertoire of endogenous HLA-bound peptides in human brain extracts from individuals with and without AD. Using human microglia xenogra...

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Literature Corpus work: d83b357d-94b3-520c-98a5-3f25a3406d49
DOI: 10.21203/rs.3.rs-9701645/v1

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