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Article

Shifting paradigms: The central role of microglia in Alzheimer's disease.

Neurobiology of disease - 1 Sept 2020

Schwabe Tina, Srinivasan Karpagam, Rhinn Herve

Abstract excerpt

Recent human genetic studies have challenged long standing hypotheses about the chain of events in Alzheimer's disease (AD), as the identification of genetic risk factors in microglial genes supports a causative role for microglia in the disease. Parallel transcriptome and histology studies at the single-cell level revealed a rich palette of microglial states affected by disease status and genetic risk factors....

Topics

Alzheimer Disease
Animals
Brain
Genetic Predisposition to Disease
Humans
Microglia

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32535152
DOI: 10.1016/j.nbd.2020.104962

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