Article

Testing a polygenic risk score for morphological microglial activation in Alzheimer’s disease and aging

2023-03-15

Abstract excerpt

Neuroinflammation and the activation of microglial cells are among the earliest events in Alzheimer’s disease (AD). However, direct observation of microglia in living people is not currently possible. Here, we indexed the heritable propensity for neuroinflammation with polygenic risk scores (PRS), using results from a recent genome-wide analysis of a validated post-mortem measure of morphological microglial activa...

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Literature Corpus work: e9802ff3-24a4-5719-bf81-5b969ffbd3c8
DOI: 10.1101/2023.03.10.23287119

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