Article

A multi-pronged human microglia response to Alzheimer’s disease Aβ pathology

2022-07-07

Abstract excerpt

Microglial activation and neuroinflammation are initial steps in the pathogenesis of Alzheimer’s disease (AD). However, studies in mouse models and human postmortem samples have yielded divergent results regarding microglia cell states relevant to AD. Here, we investigate 127,000 single cell expression profiles of human microglia isolated freshly from a xenotransplantation model for early AD. While human microglia...

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Literature Corpus work: f430ef23-2019-5694-b4d0-e6e89b7a97c2
DOI: 10.1101/2022.07.07.499139

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