Article

Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer looping

2023-03-18

Abstract excerpt

The Notch receptor is a pleiotropic signaling protein that translates intercellular ligand interactions into changes in gene expression via the nuclear localization of the Notch intracellular Domain (NICD). Using a combination of immunohistochemistry, RNA in situ, Optogenetics and super-resolution live imaging of transcription in human cells, we show that the N1ICD can form condensates that positively facilitate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e20d689b-4969-58bb-b5cd-bbce520e9925
DOI: 10.1101/2023.03.17.533124

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer loopingDOI 10.1101/2023.03.17.533124Read

Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcriptionSemantic proximity Read

Phase separation of Myc differentially modulates the transcriptomeSemantic proximity Read

RNA binding is essential for NONO condensates to modulate pre-mRNA processing of super enhancer-associated genes in neuroblastomaSemantic proximity Read

Spatially clustered pattern of transcription factor binding reveals phase-separated transcriptional condensates at super-enhancersSemantic proximity Read

Phase-Separated Transcriptional Condensates Accelerate Target-Search Process Revealed by Live-Cell Single-Molecule Imaging.Semantic proximity Read

Phase-separating fusion proteins drive cancer by dysregulating transcription through ectopic condensatesSemantic proximity Read

Liquid-like transcription condensates locally constrain chromatin in living human cellsSemantic proximity Read

Dual-role transcription factors stabilize intermediate expression levels.Semantic proximity Read

Wnt target gene activation requires β-catenin separation into biomolecular condensates.Semantic proximity Read

MORC2 Mediates Transcriptional Regulation Through Liquid-Liquid Phase SeparationSemantic proximity Read

Hijacking of transcriptional condensates by endogenous retrovirusesSemantic proximity Read

Disparate leukemia mutations converge on nuclear phase-separated condensates.Semantic proximity Read