Article

Phase separation of Myc differentially modulates the transcriptome

2022-06-29

Abstract excerpt

Dysregulation and enhanced expression of MYC transcription factors (TFs) including MYC and MYCN contribute to the majority of human cancers. For example, MYCN is amplified up to several hundred-fold in high-risk neuroblastoma. The resulting overexpression of N-myc aberrantly activates genes that are not activated at low N-myc levels and drives proliferation and cell survival. Whether increasing N-myc levels si...

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Literature Corpus work: bbeefa6c-abc1-5dc3-a09a-0097ad1590f5
DOI: 10.1101/2022.06.28.498043

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