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Article

Phase-Separated Transcriptional Condensates Accelerate Target-Search Process Revealed by Live-Cell Single-Molecule Imaging.

Cell reports - 13 Oct 2020

Kent Samantha, Brown Kyle, Yang Chou-Hsun, Alsaihati Njood, Tian Christina, Wang Haobin, Ren Xiaojun

Abstract excerpt

Compartmentalization by liquid-liquid phase separation is implicated in transcription. It remains unclear whether and how transcriptional condensates accelerate the search of transcriptional regulatory factors for their target sites. Furthermore, the molecular mechanisms by which regulatory factors nucleate on chromatin to assemble transcriptional condensates remain incompletely understood. The CBX-PRC1 complexes...

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Identifiers

PMID: 33053359
DOI: 10.1016/j.celrep.2020.108248
PMCID: PMC7593837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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